Location, Location, Location: Trafficking and Function of Secreted Proteases of Toxoplasma and Plasmodium
نویسندگان
چکیده
منابع مشابه
Toxoplasma gondii infection and behaviour - location, location, location?
Parasite location has been proposed as an important factor in the behavioural changes observed in rodents infected with the protozoan Toxoplasma gondii. During the chronic stages of infection, encysted parasites are found in the brain but it remains unclear whether the parasite has tropism for specific brain regions. Parasite tissue cysts are found in all brain areas with some, but not all, pri...
متن کاملLocation, location, location: altered transcription factor trafficking in neurodegeneration.
Neurons may be particularly sensitive to disruptions in transcription factor trafficking. Survival and injury signals must traverse dendrites or axons, in addition to soma, to affect nuclear transcriptional responses. Transcription factors exhibit continued nucleocytoplasmic shuttling; the predominant localization is regulated by binding to anchoring proteins that mask nuclear localization/expo...
متن کاملObesity and asthma: location, location, location.
T here is a worldwide epidemic of obesity. In the USA, the prevalence of obesity, defined as a body mass index (BMI) o30 kg?m, has increased among adults aged 20– 74 yrs from ,15% in the late 1970s to ,35% in 2010. Another third of the population is overweight (BMI o25 to ,30 kg?m). The obesity epidemic has impacted both developed and developing nations throughout the world. The World Health Or...
متن کاملLocation, location, location...
Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
متن کاملLocation, location, location
Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Traffic
سال: 2004
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2004.00244.x